Small molecule binding
Mitochondrial uncouplers induce proton leak by activating AAC and UCP1.
Bertholet, AM, Natale, AM, Bisignano, P, Suzuki J, Fedorenko A, Hamilton J, Brustovetsky T, Kazak L, Garrity R, Chouchani ET, Brustovetsky N, Grabe M, and Kirichok Y.
Nature 606, 180–187 (2022). [PDF]
K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Lolicato M†, Natale AM†, Abderemane-Ali F, Crottès D, Capponi S, Duman R, Wagner A, Rosenberg JM, Grabe M‡, and Minor DL‡.
Science Advances 6(44), eabc9174 (2020). [PDF | Supplement]
Inhibitor binding mode and allosteric regulation of Na+-glucose symporters.
Bisignano P, Ghezzi C, Jo H, Polizzi NF, Althoff T, Kalyanaraman C, Friemann R, Jacobson MP, Wright EM‡, and Grabe M‡.
Nature Communications 9, 5245 (2018). [PDF]